Dr Stephanie Bayol, one of the researchers, said: "It seems that a mother's diet whilst pregnant and breastfeeding is very important for the long-term health of her child. We always say: 'You are what you eat', but in fact it may also be true that you are what your mother ate."
One particular concern was fat gathering around the major organs, which has been implicated in the development of type II diabetes. The rats with unhealthy mothers were more likely to have this, even if they were weaned off the junk food diet.
However, there were interesting differences between the sexes, with the male offspring of unhealthy mothers having higher levels of insulin and normal blood sugar, while the reverse was true of females, who also tended to be fatter.
Researcher, Professor Neil Stickland, said that there was no reason why the same principles should not apply to humans. "Humans share a number of fundamental biological systems with rats, so there is good reason to assume the effects we see in rats may be repeated in humans." He said that studies in humans had found links between the weight of parents and the weight of their children.
Dr Pat Goodwin, from the Wellcome Trust, said that the study indicated that there were many different risk factors which could contribute to someone becoming overweight.
Dr Iain Frame, of the charity Diabetes UK, warned against drawing firm conclusions from animal studies. However, he said: "This study does lend some weight to the established argument that children of mothers who have poor diets during pregnancy have a higher risk of developing diabetes and heart disease later in life."
July 2008
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